Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1217	CpG ODN2216 Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	Splenocytes from these mice were found to secrete higher levels of interleukin-10 (IL-10)	ELISA	24719374	2014	Pubchem_assay
PRRID_1217	CpG ODN2216 Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	Splenocytes from these mice were found to secrete higher levels of interleukin-10 (IL-10)	ELISA	24719374	2014	Pubchem_assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1219	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	used to enhance Th1 response, also induces high levels of the anti-inflammatory, Th2- promoting cytokine IL10, which could dampen the resulting Th1 response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q9NR96.fasta	Q9NR96	1032	leads to DC maturation, increased expression of surface co-stimulatory and MHC molecules, and enhanced antigen presentation to naiÃàve T cells	ELISA	24720881	2014	Pubchem_assay
PRRID_1219	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	used to enhance Th1 response, also induces high levels of the anti-inflammatory, Th2- promoting cytokine IL10, which could dampen the resulting Th1 response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q9NR96.fasta	Q9NR96	1032	leads to DC maturation, increased expression of surface co-stimulatory and MHC molecules, and enhanced antigen presentation to naiÃàve T cells	ELISA	24720881	2014	Pubchem_assay
PRRID_1220	CpG oligonucleotides (ODN) + Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	synergistically increases IL12 secretions of DCs and thus enhances the Th1 response and antitumor immunity	NA	NA	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	NA	NA	NA	NA	ELISA	24720881	2014	NA
PRRID_1220	CpG oligonucleotides (ODN) + Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	synergistically increases IL12 secretions of DCs and thus enhances the Th1 response and antitumor immunity	NA	NA	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	NA	NA	NA	NA	ELISA	24720881	2014	NA
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1224	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1224	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1226	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	improve cell survival, prevent cell apoptosis, attenuate cardiac dysfunction after I/R19, and improve outcome in shock induced by polymicrobial sepsis or trauma hemorrhage	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	endosomes and endoplasmic reticulum	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	In situ apoptosis assay	24721797	2014	Pubchem_assay
PRRID_1226	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	improve cell survival, prevent cell apoptosis, attenuate cardiac dysfunction after I/R19, and improve outcome in shock induced by polymicrobial sepsis or trauma hemorrhage	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	endosomes and endoplasmic reticulum	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	In situ apoptosis assay	24721797	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1242	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1242	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1243	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1243	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1244	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24825061	2014	Pubchem_assay
PRRID_1244	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24825061	2014	Pubchem_assay
PRRID_1245	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA), which is presumably formed during viral infection that is produced by most viruses at some point during their replication	NA	24819172	2014	Pubchem_assay
PRRID_1245	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA), which is presumably formed during viral infection that is produced by most viruses at some point during their replication	NA	24819172	2014	Pubchem_assay
PRRID_1246	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	cell compartment	Q99MB1.fasta	Q99MB1	905	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1246	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	cell compartment	Q99MB1.fasta	Q99MB1	905	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1247	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1247	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1248	dsRNA Click for more detail	Leishmania RNA virus (LRV) L. guyanensis (others)	NA	NA	Nucleic Acid	Natural	contributes to the exacerbation of disease and impacts inflammatory responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice	Dendritic Cell, B-lymphocyte	TRIF-dependent TLR3	Q99MB1.fasta	Q99MB1	905	an increased secretion of inflammatory cytokines and chemokines and exacerbated susceptibility to infection	NA	24801628	2014	Pubchem_assay
PRRID_1248	dsRNA Click for more detail	Leishmania RNA virus (LRV) L. guyanensis (others)	NA	NA	Nucleic Acid	Natural	contributes to the exacerbation of disease and impacts inflammatory responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice	Dendritic Cell, B-lymphocyte	TRIF-dependent TLR3	Q99MB1.fasta	Q99MB1	905	an increased secretion of inflammatory cytokines and chemokines and exacerbated susceptibility to infection	NA	24801628	2014	Pubchem_assay
PRRID_1249	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Dendritic Cell, B-lymphocyte	cell compartment	Q0PQ88.fasta	Q0PQ88	896	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1249	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Dendritic Cell, B-lymphocyte	cell compartment	Q0PQ88.fasta	Q0PQ88	896	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1250	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1250	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1251	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1251	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1252	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1252	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1253	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1253	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1254	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	Q99MB1.fasta	Q99MB1	905	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1254	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	Q99MB1.fasta	Q99MB1	905	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1255	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1255	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1256	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1256	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1257	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1257	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1258	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Functional assay	24748512	2014	Pubchem_assay
PRRID_1258	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Functional assay	24748512	2014	Pubchem_assay
PRRID_1261	Endogenous DNA from dead cells Click for more detail	Mice (others)	NA	NA	Nucleic Acid	Natural	EV71 induces cellular apoptosis, resulting in tissue damage; the endogenous DNA from dead cells activate the innate immune system through TLR9.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1261	Endogenous DNA from dead cells Click for more detail	Mice (others)	NA	NA	Nucleic Acid	Natural	EV71 induces cellular apoptosis, resulting in tissue damage; the endogenous DNA from dead cells activate the innate immune system through TLR9.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1262	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1262	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1263	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1263	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1264	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1264	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1265	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1265	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1296	foreign and host RNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1296	foreign and host RNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1297	foreign and host RNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1297	foreign and host RNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1301	G/U-rich RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô-UUGUUGUUGUUGUUGUUGUU-3‚Äô	20	Nucleic Acid	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1301	G/U-rich RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô-UUGUUGUUGUUGUUGUUGUU-3‚Äô	20	Nucleic Acid	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1302	G/U-rich RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô-UUGUUGUUGUUGUUGUUGUU-3‚Äô	20	Nucleic Acid	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1302	G/U-rich RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô-UUGUUGUUGUUGUUGUUGUU-3‚Äô	20	Nucleic Acid	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1345	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1345	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1346	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1346	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1376	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1376	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1377	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	immune modulators	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1377	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	immune modulators	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1378	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1378	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1379	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	extracellular domain (ECD)	P58681.fasta	P58681	1050	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1379	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	extracellular domain (ECD)	P58681.fasta	P58681	1050	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1380	IMO-2055 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	it enhances the efficacy of antitumor agents through immune stimulation	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with advanced non-small cell lung cancer (nSClC)	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24770667	2014	Pubchem_assay
PRRID_1380	IMO-2055 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	it enhances the efficacy of antitumor agents through immune stimulation	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with advanced non-small cell lung cancer (nSClC)	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24770667	2014	Pubchem_assay
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1462	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1462	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1488	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1488	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1489	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Dendritic Cell, B-lymphocyte	cell compartment	Q8K3Z0.fasta	Q8K3Z0	1020	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1489	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Dendritic Cell, B-lymphocyte	cell compartment	Q8K3Z0.fasta	Q8K3Z0	1020	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1490	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1490	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1514	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1514	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay

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